Naloxone reverses overdose by

• A. Blocking opioid receptors and displacing opioids
• B. Inhibiting brain function
• C. Increasing pain signals
• D. Blocking dopamine receptors

Answer: (A)

Naloxone reverses opioid overdose by acting as an antagonist at opioid receptors, especially the mu receptors in the brain. It binds to these receptors with high affinity and displaces any opioids already attached, blocking further opioid effects. This rapid receptor blockade reverses the depressant impact opioids have on respiration and consciousness, effectively restoring breathing and alertness.

It doesn’t work by inhibiting brain function or increasing pain signals, and it doesn’t affect dopamine receptors. Those mechanisms would not counteract an opioid overdose and could cause additional issues. In cases of long-acting opioids, the reversal can be temporary, so symptoms can return and additional doses or medical care may be necessary.