Which of the following are signs of nicotine intoxication?

• A. Euphoria and calmness
• B. Insomnia, cardiac arrhythmias, restlessness
• C. Weight gain
• D. Sedation

Answer: (B)

Nicotine intoxication presents with stimulant-type effects that reflect activation of the sympathetic nervous system and increased arousal. Insomnia shows the wakefulness and alertness associated with nicotine’s stimulation. Cardiac arrhythmias mirror the heart’s heightened activity and potential electrical instability from increased sympathetic drive. Restlessness is a common sign of agitation and jitters that accompany stimulant intoxication as the body reacts to nicotine’s rapid dopamine and norepinephrine release.

The other options don’t fit this pattern: euphoria and calmness aren’t typical of nicotine intoxication, as nicotine usually increases alertness and can cause agitation rather than calm. Weight gain is more often linked to withdrawal or metabolic changes after quitting, not acute intoxication. Sedation runs counter to nicotine’s stimulant effects.