Which of the following is a sign of nicotine withdrawal?

• A. Euphoria, insomnia, and appetite suppression
• B. Insomnia only
• C. Craving, irritability, increased appetite, anxiety, and depression
• D. Weight gain only

Answer: (C)

Nicotine withdrawal shows up as a cluster of negative mood and physical symptoms after stopping use. The most representative signs are a strong craving for nicotine, irritability, anxiety, depressed mood, and increased appetite. These reflect how nicotine normally regulates mood and appetite, so stopping leads to craving plus mood and hunger changes.

Other options don’t fit as well. Euphoria isn’t a withdrawal sign; it’s more associated with nicotine’s effects while using or with certain substances. Appetite suppression would be opposite of what withdrawal typically causes, since increased appetite is common. Insomnia can occur but isn’t the only symptom, and weight gain can happen but isn’t the sole sign—withdrawal usually includes multiple symptoms, not just one.