Which statement best describes the relationship between Wernicke's encephalopathy and Korsakoff's psychosis?

• A. Wernicke's is an acute presentation due to thiamine deficiency; Korsakoff's is a chronic memory disorder following Wernicke's
• B. Korsakoff's is an acute liver failure
• C. Wernicke's causes irreversible renal damage
• D. Korsakoff's only occurs in non-alcoholic individuals

Answer: (A)

The main point is the progression from an acute, treatable phase to a chronic, lasting brain disorder caused by thiamine deficiency. Wernicke's encephalopathy is the sudden, acute presentation arising from thiamine deficiency and is a medical emergency that can improve with prompt thiamine treatment. Korsakoff's psychosis is the long-term consequence that follows, presenting as a chronic memory disorder—primarily severe anterograde amnesia with possible confabulation—that can be permanent due to structural brain damage (often to the mammillary bodies and thalamus). The statement also reflects that Korsakoff's is not restricted to non-alcoholics and is not about liver or kidney damage, which helps distinguish it from the other options.