Which statement differentiates benzodiazepine withdrawal from intoxication?

• A. Hallucinations are absent in withdrawal
• B. Weight gain is typical during withdrawal
• C. Agitation and tremors are common in withdrawal, while intoxication more often causes sedation
• D. Elevated liver enzymes are a hallmark of withdrawal

Answer: (C)

The key idea is how benzodiazepine effects flip between using and withdrawing. When someone is withdrawing, the nervous system becomes hyperactive, so you see agitation, tremors, anxiety, and autonomic signs like sweating and tachycardia. In contrast, intoxication produces the opposite effect: central nervous system depression with sedation, slowed movements, and impaired coordination. So statement that links withdrawal with agitation and tremors and pairs intoxication with more sedation captures the real contrast between the two states.

The other options don’t reliably differentiate withdrawal from intoxication. Hallucinations can occur with withdrawal in some cases, so claiming they’re absent isn’t a consistent rule. Weight change isn’t a defining feature of withdrawal, and elevated liver enzymes aren’t a hallmark of withdrawal either; they’re not specific or sensitive indicators of withdrawal versus intoxication.